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The man who introduced us to "The 40-Year-Old Virgin" and taught us what it's like to get "Knocked Up" is now about to show us a thing or two about being 40.

In the lead up to his latest film, "This Is 40," Judd Apatow is sitting down with MTV News' Josh Horowitz for an exclusive live hour-long interview about how he changed the landscape of modern comedy.

Apatow will also be taking questions from viewers via Twitter. To submit your questions for him, tweet them to @MTVNews using the hashtag #askjudd.

It all begins right here at 4 p.m. ET, so get your questions in now!